Somatic genomics as a discovery engine for biomedicine.

Abstract excerpt

Somatic mutations, or genetic changes occurring in cells after conception, are widespread in healthy tissues but are conventionally viewed as signs of pre-cancer or simply a consequence of aging. However, an emerging body of work has shown that somatic mutations can drive or protect against disease, which could inspire novel therapeutic strategies. The unexpected depth of genetic diversity within individuals also...

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• Biomedical Research
• Drug Discovery
• Genomics
• Mosaicism
• Mutation