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Article

Genome-wide RNAi screen identifies networks involved in intestinal stem cell regulation in Drosophila.

Cell reports - 24 Feb 2015

Zeng Xiankun, Han Lili, Singh Shree Ram, Liu Hanhan, Neumüller Ralph A, Yan Dong, Hu Yanhui, Liu Ying, Liu Wei, Lin Xinhua, Hou Steven X

Abstract excerpt

The intestinal epithelium is the most rapidly self-renewing tissue in adult animals and maintained by intestinal stem cells (ISCs) in both Drosophila and mammals. To comprehensively identify genes and pathways that regulate ISC fates, we performed a genome-wide transgenic RNAi screen in adult Drosophila intestine and identified 405 genes that regulate ISC maintenance and lineage-specific differentiation. By...

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Identifiers

PMID: 25704823
DOI: 10.1016/j.celrep.2015.01.051
PMCID: PMC4420031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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