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Article

Gastrointestinal stromal tumours: from KIT to succinate dehydrogenase.

Histopathology - 1 Jan 2014

Doyle Leona A, Hornick Jason L

Abstract excerpt

The discovery of activating mutations in the tyrosine kinase receptor genes KIT and PDGFRA has led to the development of effective targeted therapies for gastrointestinal stromal tumours (GISTs). Specific genotypes, in part, predict the response to treatment with tyrosine kinase inhibitors. However, ~10% of GISTs lack such mutations (often referred to as 'wild-type' GISTs). Recent insights into the biology of...

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Source

Identifiers

PMID: 24117705
DOI: 10.1111/his.12302

Genes

KIT
BRAF
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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