Rheumatoid arthritis in Latin Americans enriched for Amerindian ancestry is associated with loci in chromosomes 1, 12, and 13, and the HLA class II region.

doi:10.1002/art.37923

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Article

Rheumatoid arthritis in Latin Americans enriched for Amerindian ancestry is associated with loci in chromosomes 1, 12, and 13, and the HLA class II region.

Arthritis and rheumatism - 1 Jun 2013

López Herráez David, Martínez-Bueno Manuel, Riba Laura, García de la Torre Ignacio, Sacnún Mónica, Goñi Mario, Berbotto Guillermo A, Paira Sergio, Musuruana Jorge Luis, Graf César E, Alvarellos Alejandro J, Messina Osvaldo D, Babini Alejandra M, Strusberg Ingrid, Marcos Juan Carlos, Scherbarth Hugo, Spindler Alberto J, Quinteros Ana, Toloza Sergio M A, Moreno José Luis C, Catoggio Luis J, Tate Guillermo, Eimon Alicia, Citera Gustavo, Catalán Pellet Antonio, Nasswetter Gustavo G, Cardiel Mario H, Miranda Pedro, Ballesteros Francisco, Esquivel-Valerio Jorge A, Maradiaga-Ceceña Marco A, Acevedo-Vásquez Eduardo M, García García Conrado, Pons-Estel Bernardo A, Alarcón-Riquelme Marta E

Abstract excerpt

OBJECTIVE: To identify susceptibility loci for rheumatoid arthritis (RA) in Latin American individuals with admixed European and Amerindian genetic ancestry. METHODS: Genotyping was performed in 1,475 patients with RA and 1,213 control subjects, using a customized BeadArray containing 196,524 markers covering loci previously associated with various autoimmune diseases. Principal components analysis (EigenSoft...

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Identifiers

PMID: 23460240
DOI: 10.1002/art.37923

Genes

PTPN22
SPRED2
BTNL2
CCL21
ENOX1
HES5
MMEL1
NAA25
PLCH2
STAT4
TNFRSF14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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