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Article

Rheumatoid arthritis-associated RBPJ polymorphism alters memory CD4+ T cells.

Human molecular genetics - 15 Jan 2016

Orent William, Mchenry Allison R, Rao Deepak A, White Charles, Klein Hans-Ulrich, Bassil Ribal, Srivastava Gyan, Replogle Joseph M, Raj Towfique, Frangieh Michael, Cimpean Maria, Cuerdon Nicole, Chibnik Lori, Khoury Samia J, Karlson Elizabeth W, Brenner Michael B, De Jager Philip, Bradshaw Elizabeth M, Elyaman Wassim

Abstract excerpt

Notch signaling has recently emerged as an important regulator of immune responses in autoimmune diseases. The recombination signal-binding protein for immunoglobulin kappa J region (RBPJ) is a transcriptional repressor, but converts into a transcriptional activator upon activation of the canonical Notch pathway. Genome-wide association studies of rheumatoid arthritis (RA) identified a susceptibility locus,...

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Share to Arthritis, Rheumatoid
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression

Share to Immunoglobulin J Recombination Signal Sequence-Binding Protein

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Share to Receptors, Notch

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Source

Open in PubMed Open full text

Identifiers

PMID: 26604133
DOI: 10.1093/hmg/ddv474
PMCID: PMC4881829

Genes

RBPJ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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