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Article

MIF Is Necessary for Late-Stage Melanoma Patient MDSC Immune Suppression and Differentiation.

Cancer immunology research - 1 Feb 2016

Yaddanapudi Kavitha, Rendon Beatriz E, Lamont Gwyneth, Kim Eun Jung, Al Rayyan Numan, Richie Jamaal, Albeituni Sabrin, Waigel Sabine, Wise Ashley, Mitchell Robert A

Abstract excerpt

Highly aggressive cancers "entrain" innate and adaptive immune cells to suppress antitumor lymphocyte responses. Circulating myeloid-derived suppressor cells (MDSC) constitute the bulk of monocytic immunosuppressive activity in late-stage melanoma patients. Previous studies revealed that monocyte-derived macrophage migration inhibitory factor (MIF) is necessary for the immunosuppressive function of...

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Source

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Identifiers

PMID: 26603621
DOI: 10.1158/2326-6066.CIR-15-0070-T
PMCID: PMC4740231

Genes

MIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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