Article

Decitabine suppresses MDSC-induced immunosuppression through dual functional mechanism and inhibits melanoma metastasis

2023-11-28

Abstract excerpt

<title>Abstract</title> <p>Myeloid-derived suppressor cells (MDSCs) play a crucial role in promoting melanoma metastasis. Reprogramming MDSCs into mature M1 macrophages has emerged as a strategy to inhibit metastasis. Decitabine (Dec) is known to eradicate MDSCs and suppress tumor growth. In this study, we provide evidence that Dec not only reduces the MDSC population by inducing apoptosis, arresting cell cycle,...

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Literature Corpus work: 52dd2516-9b80-5126-92ff-98de56d85c00
DOI: 10.21203/rs.3.rs-3652567/v1

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