Article

G-CSF associates with poor survival in cutaneous melanoma and promotes metastasis through coordinated effects on macrophages and tumor cells

2026-06-04

Abstract excerpt

<h4>ABSTRACT</h4> Macrophage-melanoma interactions critically shape the tumor microenvironment, yet the cytokine networks driving this process remain incompletely understood. Among these, colony-stimulating factors—particularly granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF or CSF3 )—regulate myeloid cell behavior during cancer progression, although the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 26f144a0-6383-59ce-a32c-725aef44f510
DOI: 10.64898/2026.06.02.729497

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

G-CSF associates with poor survival in cutaneous melanoma and promotes metastasis through coordinated effects on macrophages and tumor cellsDOI 10.64898/2026.06.02.729497Read

Adverse prognosis of GM-CSF expression in human cutaneous melanomaSemantic proximity Read

Chemokine profiling of melanoma-macrophage crosstalk identifies CCL8 and CCL15 as prognostic factors in cutaneous melanomaSemantic proximity Read

Melanoma‐derived conditioned media efficiently induce the differentiation of monocytes to macrophages that display a highly invasive gene signatureSemantic proximity Read

Single-cell hdWGCNA reveals Metastatic protective macrophages and development of deep learning model in uveal melanomaSemantic proximity Read

Single-cell characterization of macrophages in uveal melanoma uncovers transcriptionally heterogeneous subsets conferring poor prognosis and aggressive behaviorSemantic proximity Read

Translating genetics into tissue: inflammatory cytokine-producing TAMs and PD-L1 tumor expression as poor prognosis factors in cutaneous melanomaSemantic proximity Read

Functionally and metabolically divergent melanoma-associated macrophages originate from common bone-marrow precursorsSemantic proximity Read

Melanoma stem cells drive macrophage reprogramming to a hybrid phenotype, modulating melanoma stemness and compromising NK cell-mediated immunity.Semantic proximity Read

CD206-positive myeloid cells bind galectin-9 and promote a tumor-supportive microenvironment.Semantic proximity Read

Changes in the gene expression profile of A375 human melanoma cells induced by overexpression of multifunctional pigment epithelium-derived factor.Semantic proximity Read

E2F1-induced autocrine IL-6 inflammatory loop mediates cancer-immune crosstalk that predicts T cell phenotype switching and therapeutic responsiveness.Semantic proximity Read

Linking Transcriptomic and Imaging Data Defines Features of a Favorable Tumor Immune Microenvironment and Identifies a Combination Biomarker for Primary MelanomaSemantic proximity Read