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Article

Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2.

BMC genomics - 21 Nov 2015

Zepeda-Mendoza Cinthya J, Mukhopadhyay Swagatam, Wong Emily S, Harder Nathalie, Splinter Erik, de Wit Elzo, Eckersley-Maslin Melanie A, Ried Thomas, Eils Roland, Rohr Karl, Mills Alea, de Laat Wouter, Flicek Paul, Sengupta Anirvan M, Spector David L

Abstract excerpt

BACKGROUND: Circular chromosome conformation capture (4C) has provided important insights into three dimensional (3D) genome organization and its critical impact on the regulation of gene expression. We developed a new quantitative framework based on polymer physics for the analysis of paired-end sequencing 4C (PE-4Cseq) data. We applied this strategy to the study of chromatin interaction changes upon a 4.3 Mb...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26589460
DOI: 10.1186/s12864-015-2137-5
PMCID: PMC4654810

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CTCF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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