Article
Primed CRISPR DNA uptake in Pyrococcus furiosus.
Nucleic acids research - 19 Jun 2020
Garrett Sandra, Shiimori Masami, Watts Elizabeth A, Clark Landon, Graveley Brenton R, Terns Michael P
Abstract excerpt
CRISPR-Cas adaptive immune systems are used by prokaryotes to defend against invaders like viruses and other mobile genetic elements. Immune memories are stored in the form of 'spacers' which are short DNA sequences that are captured from invaders and added to the CRISPR array during a process called 'adaptation'. Spacers are transcribed and the resulting CRISPR (cr)RNAs assemble with different Cas proteins to...
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