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Article

Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity.

Human molecular genetics - 15 Jan 2016

Tenreiro Sandra, Rosado-Ramos Rita, Gerhardt Ellen, Favretto Filippo, Magalhães Filipa, Popova Blagovesta, Becker Stefan, Zweckstetter Markus, Braus Gerhard H, Outeiro Tiago Fleming

Abstract excerpt

Synucleins belong to a family of intrinsically unstructured proteins that includes alpha-synuclein (aSyn), beta-synuclein (bSyn) and gamma-synuclein (gSyn). aSyn is the most studied member of the synuclein family due to its central role in genetic and sporadic forms of Parkinson's disease and other neurodegenerative disorders known as synucleionopathies. In contrast, bSyn and gSyn have been less studied, but...

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PMID: 26586132
DOI: 10.1093/hmg/ddv470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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