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Article

alpha-Synuclein budding yeast model: toxicity enhanced by impaired proteasome and oxidative stress.

Journal of molecular neuroscience : MN - 1 Jan 2006

Sharma Nijee, Brandis Katrina A, Herrera Sara K, Johnson Brandon E, Vaidya Tulaza, Shrestha Ruja, Debburman Shubhik K

Abstract excerpt

Parkinson's disease (PD) is a common neurodegenerative disorder that results from the selective loss of midbrain dopaminergic neurons. Misfolding and aggregation of the protein alpha-synuclein, oxidative damage, and proteasomal impairment are all hypotheses for the molecular cause of this selective neurotoxicity. Here, we describe a Saccharomyces cerevisiae model to evaluate the misfolding, aggregation, and...

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Identifiers

PMID: 16679556
DOI: 10.1385/JMN:28:2:161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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