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Article

Alpha-synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast.

Genetics - 1 May 2005

Dixon Cheryl, Mathias Neal, Zweig Richard M, Davis Donnie A, Gross David S

Abstract excerpt

A pathological feature of Parkinson's disease is the presence of Lewy bodies within selectively vulnerable neurons. These are ubiquitinated cytoplasmic inclusions containing alpha-synuclein, an abundant protein normally associated with presynaptic terminals. Point mutations in the alpha-synuclein gene (A30P and A53T), as well as triplication of the wild-type (WT) locus, have been linked to autosomal dominant...

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Identifiers

PMID: 15744056
DOI: 10.1534/genetics.104.035493
PMCID: PMC1449710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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