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From yeast to patient neurons and back again: Powerful new discovery platforms

14 Aug 2014

Abstract excerpt

No disease-modifying therapies are available for synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple systems atrophy (MSA). The lack of therapies has been impeded by a paucity of validated drug targets and problematic cell-based model systems. New approaches are therefore needed to identify genes and compounds that directly target the underlying cellular...

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PMID: 25131316
DOI: 10.1002/mds.25989

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