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Article

Gag non-cleavage site mutations contribute to full recovery of viral fitness in protease inhibitor-resistant human immunodeficiency virus type 1.

Antimicrobial agents and chemotherapy - 1 Feb 2004

Myint Lay, Matsuda Masakazu, Matsuda Zene, Yokomaku Yoshiyuki, Chiba Tomoko, Okano Aiko, Yamada Kaneo, Sugiura Wataru

Abstract excerpt

It is well documented that human immunodeficiency virus type 1 (HIV-1) Gag cleavage site mutations (CSMs) emerge in conjunction with various HIV-1 mutations for protease inhibitor (PI) resistance and improve viral replication capacity, which is reduced by acquisition of the resistance. However, CSMs are not the only mutations that emerge in Gag during treatment; many mutations other than CSMs (non-CSMs) have been...

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Source

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Identifiers

PMID: 14742193
DOI: 10.1128/AAC.48.2.444-452.2004
PMCID: PMC321554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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