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Article

Position-specific automated processing of V3 env ultra-deep pyrosequencing data for predicting HIV-1 tropism.

Scientific reports - 20 Nov 2015

Jeanne Nicolas, Saliou Adrien, Carcenac Romain, Lefebvre Caroline, Dubois Martine, Cazabat Michelle, Nicot Florence, Loiseau Claire, Raymond Stéphanie, Izopet Jacques, Delobel Pierre

Abstract excerpt

HIV-1 coreceptor usage must be accurately determined before starting CCR5 antagonist-based treatment as the presence of undetected minor CXCR4-using variants can cause subsequent virological failure. Ultra-deep pyrosequencing of HIV-1 V3 env allows to detect low levels of CXCR4-using variants that current genotypic approaches miss. However, the computation of the mass of sequence data and the need to identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26585833
DOI: 10.1038/srep16944
PMCID: PMC4653658

Genes

CXCR4
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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