The genotypic false positive rate determined by V3 population sequencing can predict the burden of HIV-1 CXCR4-using species detected by pyrosequencing.

doi:10.1371/journal.pone.0053603

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Article

The genotypic false positive rate determined by V3 population sequencing can predict the burden of HIV-1 CXCR4-using species detected by pyrosequencing.

PloS one - 1 Jan 2013

Svicher Valentina, Cento Valeria, Rozera Gabriella, Abbate Isabella, Santoro Maria Mercedes, Armenia Daniele, Fabeni Lavinia, Bruselles Alessandro, Latini Alessandra, Palamara Guido, Micheli Valeria, Rizzardini Giuliano, Gori Caterina, Forbici Federica, Ippolito Giuseppe, Andreoni Massimo, Antinori Andrea, Ceccherini-Silberstein Francesca, Capobianchi Maria Rosaria, Perno Carlo Federico

Abstract excerpt

OBJECTIVE: The false-positive rate (FPR) is a percentage-score provided by Geno2Pheno-algorithm indicating the likelihood that a V3-sequence is falsely predicted as CXCR4-using. We evaluated the correlation between FPR obtained by V3 population-sequencing and the burden of CXCR4-using variants detected by V3 ultra-deep sequencing (UDPS) and Enhanced-Sensitivity Trofile assay (ESTA). METHODS: 54 HIV-1 B-subtype...

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PMID: 23341955
DOI: 10.1371/journal.pone.0053603
PMCID: PMC3544916

Genes

CXCR4
CCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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