Article
Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region.
Antiviral research - 1 Oct 2014
Irving William L, Rupp Daniel, McClure C Patrick, Than Lwin Mar, Titman Andrew, Ball Jonathan K, Steinmann Eike, Bartenschlager Ralf, Pietschmann Thomas, Brown Richard J P
Abstract excerpt
A new generation of drugs targeting the non-structural (NS) proteins of the Hepatitis C virus (HCV) will substantially increase treatment success rates, reducing global infections. Amongst the NS proteins, the NS3 protease represents an important drug target, responsible for liberation of mature NS proteins from the nascent HCV polyprotein and suppression of host innate immunity. Despite this, the evolutionary...
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