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Article

Use of Four Next-Generation Sequencing Platforms to Determine HIV-1 Coreceptor Tropism

14 Nov 2012

Abstract excerpt

HIV-1 coreceptor tropism assays are required to rule out the presence of CXCR4-tropic (non-R5) viruses prior treatment with CCR5 antagonists. Phenotypic (e.g., Trofile™, Monogram Biosciences) and genotypic (e.g., population sequencing linked to bioinformatic algorithms) assays are the most widely used. Although several next-generation sequencing (NGS) platforms are available, to date all published deep sequencing...

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PMID: 23166726
DOI: 10.1371/journal.pone.0049602

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