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T-cell receptor–HLA-DRB1 associations suggest specific antigens in pulmonary sarcoidosis

19 Nov 2015

Abstract excerpt

In pulmonary sarcoidosis, CD4(+) T-cells expressing T-cell receptor Vα2.3 accumulate in the lungs of HLA-DRB1*03(+) patients. To investigate T-cell receptor-HLA-DRB1*03 interactions underlying recognition of hitherto unknown antigens, we performed detailed analyses of T-cell receptor expression on bronchoalveolar lavage fluid CD4(+) T-cells from sarcoidosis patients.Pulmonary sarcoidosis patients (n=43) underwent...

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Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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PMID: 26585430
DOI: 10.1183/13993003.01209-2015

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