Article
HLA-DRB1 allele frequencies and C4 copy number variation in Finnish sarcoidosis patients and associations with disease prognosis.
Human immunology - 1 Jan 2012
Wennerström Annika, Pietinalho Anne, Vauhkonen Hanna, Lahtela Laura, Palikhe Anil, Hedman Jouni, Purokivi Minna, Varkki Essi, Seppänen Mikko, Lokki Marja-Liisa, Selroos Olof
Abstract excerpt
Sarcoidosis is a multiorgan immune-mediated disease of unknown etiology with varying clinical pictures. We studied 3 genes in the major histocompatibility complex region (HLA-DRB1 and complement C4A and C4B) in patients with resolved disease after a 2-year follow-up (n = 90) and in patients whose disease was still active at that time point (n = 98) and compared them with controls (n = 150). Our primary aim was to...
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