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Article

Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival.

Neoplasia (New York, N.Y.) - 1 Oct 2015

Mullany Lisa K, Wong Kwong-Kwok, Marciano David C, Katsonis Panagiotis, King-Crane Erin R, Ren Yi Athena, Lichtarge Olivier, Richards JoAnne S

Abstract excerpt

Evolutionary Action analyses of The Cancer Gene Atlas data sets show that many specific p53 missense and gain-of-function mutations are selectively overrepresented and functional in high-grade serous ovarian cancer (HGSC). As homozygous alleles, p53 mutants are differentially associated with specific loss of heterozygosity (R273; chromosome 17); copy number variation (R175H; chromosome 9); and up-stream,...

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Identifiers

PMID: 26585234
DOI: 10.1016/j.neo.2015.10.003
PMCID: PMC4656807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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