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Article

Targeted DNA sequencing of high-grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression.

International journal of cancer - 1 Jul 2024

Holý Petr, Hlaváč Viktor, Šeborová Karolína, Šůsová Simona, Tesařová Tereza, Rob Lukáš, Hruda Martin, Bouda Jiří, Bartáková Alena, Mrhalová Marcela, Kopečková Kateřina, Al Obeed Allah Mohammad, Špaček Jiří, Sedláková Iva, Souček Pavel, Václavíková Radka

Abstract excerpt

High-grade serous ovarian carcinoma (HGSC) is the most common subtype of ovarian cancer and is among the most fatal gynecological malignancies worldwide, due to late diagnosis at advanced stages and frequent therapy resistance. In 47 HGSC patients, we assessed somatic and germline genetic variability of a custom panel of 144 known or suspected HGSC-related genes by high-coverage targeted DNA sequencing to...

Topics

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Cystadenocarcinoma, Serous
Drug Resistance, Neoplasm
Exome Sequencing
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Germ-Line Mutation

Ovarian Neoplasms

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 38447012
DOI: 10.1002/ijc.34908

Genes

TP53
CFTR
BRCA1
CSMD1
DNAH14
RAD51
RAD51B

Provenance

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