Article
Characterizing genomic differences of human cancer stratified by the TP53 mutation status.
Molecular genetics and genomics : MGG - 1 Jun 2018
Wang Mengyao, Yang Chao, Zhang Xiuqing, Li Xiangchun
Abstract excerpt
The key roles of the TP53 mutation in cancer have been well established. TP53 is the most frequently mutated gene, and its inactivation is widespread among human cancer types. However, the landscape of genomic alterations in human cancers stratified by the TP53 mutation has not yet been described. We obtained somatic mutation and copy number change data of 6551 regular-mutated samples from the Cancer Genome Atlas...
Topics
- Cell Survival
- DNA Copy Number Variations
- DNA Mutational Analysis
- Databases, Genetic
- Gene Regulatory Networks
- Genetic Predisposition to Disease
- Humans
- Mutation
- Neoplasms
- Tumor Suppressor Protein p53