Article
The genomic landscape of TP53 and p53 annotated high grade ovarian serous carcinomas from a defined founder population associated with patient outcome.
PloS one - 1 Jan 2012
Wojnarowicz Paulina M, Oros Kathleen Klein, Quinn Michael C J, Arcand Suzanna L, Gambaro Karen, Madore Jason, Birch Ashley H, de Ladurantaye Manon, Rahimi Kurosh, Provencher Diane M, Mes-Masson Anne-Marie, Greenwood Celia M T, Tonin Patricia N
Abstract excerpt
High-grade ovarian serous carcinomas (HGSC) are characterized by TP53 mutations and non-random patterns of chromosomal anomalies, where the nature of the TP53 mutation may correlate with clinical outcome. However, the frequency of common somatic genomic events occurring in HGSCs from demographically defined populations has not been explored. Whole genome SNP array, and TP53 mutation, gene and protein expression...
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