Article
Identification of key amino acid residues responsible for internal and external pH sensitivity of Orai1/STIM1 channels.
Scientific reports - 18 Nov 2015
Tsujikawa Hiroto, Yu Albert S, Xie Jia, Yue Zhichao, Yang Wenzhong, He Yanlin, Yue Lixia
Abstract excerpt
Changes of intracellular and extracellular pH are involved in a variety of physiological and pathological processes, in which regulation of the Ca(2+) release activated Ca(2+) channel (I CRAC) by pH has been implicated. Ca(2+) entry mediated by I CRAC has been shown to be regulated by acidic or alkaline pH. Whereas several amino acid residues have been shown to contribute to extracellular pH (pHo) sensitivity,...
Topics
- Amino Acid Motifs
- Amino Acids
- Calcium
- Calcium Channels
- Extracellular Space
- HEK293 Cells
- Humans
- Hydrogen-Ion Concentration
- Intracellular Space
- Membrane Potentials
- Membrane Proteins