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Article

Identification of key amino acid residues responsible for internal and external pH sensitivity of Orai1/STIM1 channels.

Scientific reports - 18 Nov 2015

Tsujikawa Hiroto, Yu Albert S, Xie Jia, Yue Zhichao, Yang Wenzhong, He Yanlin, Yue Lixia

Abstract excerpt

Changes of intracellular and extracellular pH are involved in a variety of physiological and pathological processes, in which regulation of the Ca(2+) release activated Ca(2+) channel (I CRAC) by pH has been implicated. Ca(2+) entry mediated by I CRAC has been shown to be regulated by acidic or alkaline pH. Whereas several amino acid residues have been shown to contribute to extracellular pH (pHo) sensitivity,...

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Source

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Identifiers

PMID: 26576490
DOI: 10.1038/srep16747
PMCID: PMC4649748

Genes

STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Identification of key amino acid residues responsible for internal and external pH sensitivity of Orai1/STIM1 channels.PMID 26576490Read ↗

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