Article
A conserved cytoplasmic region of ROMK modulates pH sensitivity, conductance, and gating.
The American journal of physiology - 1 Oct 1997
Choe H, Zhou H, Palmer L G, Sackin H
Abstract excerpt
ROMK channels play a key role in overall K balance by controlling K secretion across the apical membrane of mammalian cortical collecting tubule. In contrast to the family of strong inward rectifiers (IRKs), ROMK channels are markedly sensitive to intracellular pH. Using Xenopus oocytes, we have...
Topics
- Acetates
- Amino Acid Sequence
- Animals
- Conserved Sequence
- Cytoplasm
- Electric Conductivity
- Female
- Hydrogen
- Hydrogen-Ion Concentration
- Intracellular Membranes
- Ion Channel Gating
- Molecular Sequence Data
- Mutation
- Oocytes
- Potassium Channels
- Potassium Channels, Inwardly Rectifying
- Solutions
- Xenopus laevis