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Article

A conserved cytoplasmic region of ROMK modulates pH sensitivity, conductance, and gating.

The American journal of physiology - 1 Oct 1997

Choe H, Zhou H, Palmer L G, Sackin H

Abstract excerpt

ROMK channels play a key role in overall K balance by controlling K secretion across the apical membrane of mammalian cortical collecting tubule. In contrast to the family of strong inward rectifiers (IRKs), ROMK channels are markedly sensitive to intracellular pH. Using Xenopus oocytes, we have confirmed this pH sensitivity at both the single-channel and whole cell level. Reduction of oocyte pH from 6.8 to 6.4...

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Source

Identifiers

PMID: 9362329
DOI: 10.1152/ajprenal.1997.273.4.F516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A conserved cytoplasmic region of ROMK modulates pH sensitivity, conductance, and gating.PMID 9362329Read ↗

Functional and structural characterization of PKA-mediated pHi gating of ROMK1 channels.Semantic proximity Read ↗

Subunit-subunit interactions are critical for proton sensitivity of ROMK: evidence in support of an intermolecular gating mechanism.Semantic proximity Read ↗

pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome.Semantic proximity Read ↗

pH-dependent modulation of the cloned renal K+ channel, ROMK.Semantic proximity Read ↗

Non-basic amino acids in the ROMK1 channels via an appropriate distance modulate PIP2 regulated pHi-gating.Semantic proximity Read ↗

Requirement of multiple protein domains and residues for gating K(ATP) channels by intracellular pH.Semantic proximity Read ↗

Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue.Semantic proximity Read ↗

Identification of key amino acid residues responsible for internal and external pH sensitivity of Orai1/STIM1 channels.Semantic proximity Read ↗

Protein kinase C (PKC)-induced phosphorylation of ROMK1 is essential for the surface expression of ROMK1 channels.Semantic proximity Read ↗

pH dependence of the Slc4a11-mediated H+ conductance is influenced by intracellular lysine residues and modified by disease-linked mutations.Semantic proximity Read ↗

Molecular mechanism of a COOH-terminal gating determinant in the ROMK channel revealed by a Bartter's disease mutation.Semantic proximity Read ↗

Involvement of histidine residues in proton sensing of ROMK1 channel.Semantic proximity Read ↗

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