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Article

Intracellular pH regulates the strength of the intrinsic inward rectification of Kir4.1/Kir5.1 channels.

Pflugers Archiv : European journal of physiology - 1 May 2025

Aréchiga-Figueroa Iván A, Marmolejo-Murillo Leticia G, Delgado-Ramírez Mayra, Zamora-Cárdenas Rodrigo, Moreno-Galindo Eloy G, Ferrer Tania, Navarro-Polanco Ricardo A, Sánchez-Chapula José A, Rodríguez-Menchaca Aldo A

Abstract excerpt

Kir4.1/Kir5.1 channels play a crucial role in important physiological functions, notably in the kidneys and brain. A hallmark of these channels is the coexistence of two mechanisms of inward rectification: the classical "extrinsic" inward rectification induced by polyamines and Mg2+ blocking the pore, and a novel "intrinsic" voltage-dependent mechanism driven by K+ flux. Previous studies have shown that...

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PMID: 40133722
DOI: 10.1007/s00424-025-03079-3

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Intracellular pH regulates the strength of the intrinsic inward rectification of Kir4.1/Kir5.1 channels.PMID 40133722Read ↗

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