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Article

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate.

Nature communications - 21 Feb 2017

Yamashita Megumi, Yeung Priscilla S-W, Ing Christopher E, McNally Beth A, Pomès Régis, Prakriya Murali

Abstract excerpt

Store-operated Ca2+ release-activated Ca2+ (CRAC) channels constitute a major pathway for Ca2+ influx and mediate many essential signalling functions in animal cells, yet how they open remains elusive. Here, we investigate the gating mechanism of the human CRAC channel Orai1 by its activator, stromal interacting molecule 1 (STIM1). We find that two rings of pore-lining residues, V102 and F99, work together to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28220789
DOI: 10.1038/ncomms14512
PMCID: PMC5321763

Genes

STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate.PMID 28220789Read ↗

Gated regulation of CRAC channel ion selectivity by STIM1.Semantic proximity Read ↗

Review: Structure and Activation Mechanisms of CRAC Channels.Semantic proximity Read ↗

Orai channel pore properties and gating by STIM: implications from the Orai crystal structure.Semantic proximity Read ↗

Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.Semantic proximity Read ↗

Interhelical interactions within the STIM1 CC1 domain modulate CRAC channel activation.Semantic proximity Read ↗

CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions.Semantic proximity Read ↗

Activation of STIM1-Orai1 involves an intramolecular switching mechanism.Semantic proximity Read ↗

Sequential Steps of CRAC Channel Activation.Semantic proximity Read ↗

Orai1 is an essential pore subunit of the CRAC channel.Semantic proximity Read ↗

A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating.Semantic proximity Read ↗

A single amino acid deletion in the ER Ca2+ sensor STIM1 reverses the in vitro and in vivo effects of the Stormorken syndrome-causing R304W mutation.Semantic proximity Read ↗

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.Semantic proximity Read ↗

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