Article
Mutations causing neurodegeneration in Caenorhabditis elegans drastically alter the pH sensitivity and inactivation of the mammalian H+-gated Na+ channel MDEG1.
The Journal of biological chemistry - 19 Jun 1998
Champigny G, Voilley N, Waldmann R, Lazdunski M
Abstract excerpt
The mammalian degenerin MDEG1 belongs to the nematode degenerin/epithelial Na+ channel superfamily. It is constitutively activated by the same mutations that cause gain-of-function of the Caenorhabditis elegans degenerins and neurodegeneration. ASIC and DRASIC, which were recently cloned, are str...
Topics
- Amino Acid Substitution
- Animals
- Caenorhabditis elegans
- Degenerin Sodium Channels
- Epithelial Sodium Channels
- Hydrogen-Ion Concentration
- Ion Channels
- Kinetics
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Nerve Tissue Proteins
- Neurons
- Potassium Channels
- Sodium Channels
- Xenopus