Article
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.
Cell metabolism - 1 Jan 2005
Oishi Yumiko, Manabe Ichiro, Tobe Kazuyuki, Tsushima Kensuke, Shindo Takayuki, Fujiu Katsuhito, Nishimura Go, Maemura Koji, Yamauchi Toshimasa, Kubota Naoto, Suzuki Ryo, Kitamura Toshio, Akira Shizuo, Kadowaki Takashi, Nagai Ryozo
Abstract excerpt
Krüppel-like factor 5 (KLF5) is a zinc-finger transcription factor known to play a pivotal role in the pathogenesis of cardiovascular disease. Here, we show that neonatal heterozygous KLF5 knockout mice exhibit a marked deficiency in white adipose tissue development, suggesting that KLF5 is also required for adipogenesis. In 3T3-L1 preadipocytes, KLF5 expression was induced at an early stage of differentiation,...
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