Article
Sectm1a deficiency aggravates inflammation-triggered cardiac dysfunction through disruption of LXRα signalling in macrophages.
Cardiovascular research - 22 Feb 2021
Li Yutian, Deng Shan, Wang Xiaohong, Huang Wei, Chen Jing, Robbins Nathan, Mu Xingjiang, Essandoh Kobina, Peng Tianqing, Jegga Anil G, Rubinstein Jack, Adams David E, Wang Yigang, Peng Jiangtong, Fan Guo-Chang
Abstract excerpt
AIMS: Cardiac dysfunction is a prevalent comorbidity of disrupted inflammatory homeostasis observed in conditions such as sepsis (acute) or obesity (chronic). Secreted and transmembrane protein 1a (Sectm1a) has previously been implicated to regulate inflammatory responses, yet its role in inflammation-associated cardiac dysfunction is virtually unknown. METHODS AND RESULTS: Using the CRISPR/Cas9 system, we...
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