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Article

Genetic deficiency of CCL5 exhibits the phenotypes of HFpEF and aggravates apoptotic cardiomyopathy in HFD-induced diabetic mice.

Journal of molecular medicine (Berlin, Germany) - 1 Nov 2025

Huang Jiung-Pang, Chen Kuan-Hsing, Hsieh Po-Shiuan, Kuo Chao-Yu, Yu Chao-Lan, Hung Li-Man

Abstract excerpt

The chemokine C-C motif ligand 5 (CCL5) has been implicated in both metabolic dysfunction and cardiovascular diseases; however, its specific role in the pathophysiology of diabetic cardiomyopathy and heart failure remains incompletely understood. This study investigates the impact of CCL5 on the progression of diabetic cardiomyopathy and heart failure. A mouse model of obesity, insulin resistance, and diabetes...

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Share to Apoptosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40940528
DOI: 10.1007/s00109-025-02579-0

Genes

CCL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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