Article
SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.
Nature medicine - 1 Jun 2008
Oishi Yumiko, Manabe Ichiro, Tobe Kazuyuki, Ohsugi Mitsuru, Kubota Tetsuya, Fujiu Katsuhito, Maemura Koji, Kubota Naoto, Kadowaki Takashi, Nagai Ryozo
Abstract excerpt
Obesity and metabolic syndrome are increasingly recognized as major risk factors for cardiovascular disease. Herein we show that Krüppel-like transcription factor 5 (KLF5) is a crucial regulator of energy metabolism. Klf5(+/-) mice were resistant to high fat-induced obesity, hypercholesterolemia and glucose intolerance, despite consuming more food than wild-type mice. This may in part reflect their enhanced...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.