Article
IL-12 induced the generation of IL-21- and IFN-γ-co-expressing poly-functional CD4+ T cells from human naive CD4+ T cells.
Cell cycle (Georgetown, Tex.) - 1 Jan 2015
Yu Sifei, Jia Lei, Zhang Yannan, Zhong Junmin, Yang Binyan, Wu Changyou
Abstract excerpt
Interleukine-12 is critical for the differentiation of Th1 cells and can improve the development of Th1 cells with Tfh cell features in mouse model. Human effector CD4(+) T cells also exhibit poly-functionality by co-expressing IL-21 and IFN-γ. However, the effects of IL-12 on regulating generation of human IL-21- and IFN-γ-expressing CD4(+) T cells are still incompletely understood. Our studies found that IL-12...
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