Article
Human B cells promote T-cell plasticity to optimize antibody response by inducing coexpression of T(H)1/T(FH) signatures.
The Journal of allergy and clinical immunology - 1 Apr 2015
de Wit Jelle, Jorritsma Tineke, Makuch Mateusz, Remmerswaal Ester B M, Klaasse Bos Hanny, Souwer Yuri, Neefjes Jacques, Ten Berge Ineke J M, van Ham S Marieke
Abstract excerpt
BACKGROUND: B cells mediate humoral immunity against pathogens but also direct CD4(+) T-cell responses. Recent plasticity studies in mice have challenged the concept of strict fate commitment during CD4(+) T-cell differentiation into distinct subsets. OBJECTIVE: We sought to elucidate the contribution of human antigen-primed B cells in CD4(+) T-cell responses that support humoral immunity. METHODS: CD4(+) T-cell...
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