Article

RNA-sensing pattern-recognition receptors synergize with TLR2 or dectin-1 to trigger high production of IL-12p70 by human dendritic cells

2022-10-03

Abstract excerpt

IL-12p70 is crucial for T helper 1 polarization and the generation of type 1 immunity that is required to fight cancer and intracellular pathogens. Therefore, strategies to optimize the production of IL-12p70 by dendritic cells (DCs) may significantly improve the efficacy of vaccines and immunotherapies for cancer. However, the rules governing the production of IL-12p70 remain obscure. Here, we stimulated pattern...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9651a00a-a2d3-5a25-996f-369fec9effa9
DOI: 10.1101/2022.10.03.510527

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RNA-sensing pattern-recognition receptors synergize with TLR2 or dectin-1 to trigger high production of IL-12p70 by human dendritic cellsDOI 10.1101/2022.10.03.510527Read

Interferon-β paracrine signaling mediates synergy between TLR3 and TRIF-independent TLR pathwaysSemantic proximity Read

Linked Toll-Like Receptor Triagonists Stimulate Distinct, Combination-Dependent Innate Immune ResponsesSemantic proximity Read

TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells <i>in vitro</i> and generate unique cellular immune responses in influenza vaccinationSemantic proximity Read

The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseasesSemantic proximity Read

Amplification of poly(I:C)-induced interleukin-6 production in human bronchial epithelial cells by priming with interferon-γSemantic proximity Read

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses.Semantic proximity Read

Intradermal delivery of TLR agonists in a human explant skin model: preferential activation of migratory dendritic cells by polyribosinic-polyribocytidylic acid and peptidoglycans.Semantic proximity Read

Interferon-alpha and viral triggers promote functional maturation of human monocyte-derived dendritic cells.Semantic proximity Read

Effect of multiple activation stimuli on the generation of Th1-polarizing dendritic cells.Semantic proximity Read

Hiltonol and Protamine-RNA stimulation induce an immune-activating transcriptome profile in cDC1sSemantic proximity Read

CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells.Semantic proximity Read

TLR, NLR Agonists, and Other Immune Modulators as Infectious Disease Vaccine AdjuvantsSemantic proximity Read