Article
Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.
PloS one - 1 Jan 2011
Yu Yuming, Zitzner Jennifer R, Houlihan Josetta, Herrera Nancy, Xu Luting, Miller Joshua, Mathew James M, Tambur Anat R, Luo Xunrong
Abstract excerpt
Human CD8(+) regulatory T cells, particularly the CD8(+)CD28(-) T suppressor cells, have emerged as an important modulator of alloimmunity. Understanding the conditions under which these cells are induced and/or expanded would greatly facilitate their application in future clinical trials. In the current study, we develop a novel strategy that combines common gamma chain (γc) cytokines IL-2, IL-7 and IL-15 and...
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