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A Role for IFITM Proteins in Restriction of Mycobacterium tuberculosis Infection

25 Oct 2015

Abstract excerpt

The interferon (IFN)-induced transmembrane (IFITM) proteins are critical mediators of the host antiviral response. Here, we expand the role of IFITM proteins to host defense against intracellular bacterial infection by demonstrating that they restrict Mycobacterium tuberculosis (MTb) intracellular growth. Simultaneous knockdown of IFITM1, IFITM2, and IFITM3 by RNAi significantly enhances MTb growth in human...

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PMID: 26565900
DOI: 10.1016/j.celrep.2015.09.048

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