Article
Defining the range of pathogens susceptible to Ifitm3 restriction using a knockout mouse model.
PloS one - 1 Jan 2013
Everitt Aaron R, Clare Simon, McDonald Jacqueline U, Kane Leanne, Harcourt Katherine, Ahras Malika, Lall Amar, Hale Christine, Rodgers Angela, Young Douglas B, Haque Ashraful, Billker Oliver, Tregoning John S, Dougan Gordon, Kellam Paul
Abstract excerpt
The interferon-inducible transmembrane (IFITM) family of proteins has been shown to restrict a broad range of viruses in vitro and in vivo by halting progress through the late endosomal pathway. Further, single nucleotide polymorphisms (SNPs) in its sequence have been linked with risk of developing severe influenza virus infections in humans. The number of viruses restricted by this host protein has continued to...
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