Article

Molecular Basis for Interferon-mediated Pathogen Restriction in Human Cells

2022-10-21

Abstract excerpt

To define novel mechanisms for cellular immunity to the intracellular pathogen Toxoplasma gondii , we performed a genome-wide CRISPR loss-of-function screen to provide an unbiased assessment of genes important for IFN-γ-dependent growth restriction. We revealed a previously unknown role for the tumor suppressor NF2/Merlin for maximum induction of Interferon Stimulated Genes (ISG), which are positively regulated b...

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Literature Corpus work: 4ecda87f-1571-541f-b09b-244816deea3d
DOI: 10.1101/2022.10.21.513197

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