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Article

NUR77 exerts a protective effect against inflammatory bowel disease by negatively regulating the TRAF6/TLR-IL-1R signalling axis.

The Journal of pathology - 1 Feb 2016

Wu Hua, Li Xiu-Ming, Wang Jing-Ru, Gan Wen-Juan, Jiang Fu-Quan, Liu Yao, Zhang Xin-Dao, He Xiao-Shun, Zhao Yuan-Yuan, Lu Xing-Xing, Guo Yan-Bing, Zhang Xiao-Kun, Li Jian-Ming

Abstract excerpt

Nur77, an immediate-early response gene, participates in a wide range of biological functions. Its human homologue, NUR77, is known by several names and has the HGNC-approved gene symbol NR4A1. However, the role of Nur77 in inflammatory bowel disease (IBD) and its underlying mechanisms remain elusive. Here, using public data from the International Inflammatory Bowel Disease Genetics Consortium (IIBDGC) on the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26564988
DOI: 10.1002/path.4670

Genes

TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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