Article
The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.
Cancer cell - 15 Nov 2011
Zaki Md Hasan, Vogel Peter, Malireddi R K Subbarao, Body-Malapel Mathilde, Anand Paras K, Bertin John, Green Douglas R, Lamkanfi Mohamed, Kanneganti Thirumala-Devi
Abstract excerpt
NLRP12 is a member of the intracellular Nod-like receptor (NLR) family that has been suggested to downregulate the production of inflammatory cytokines, but its physiological role in regulating inflammation has not been characterized. We analyzed mice deficient in Nlrp12 to study its role in inflammatory diseases such as colitis and colorectal tumorigenesis. We show that Nlrp12-deficient mice are highly...
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