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Ancient Nuclear Receptor VDR With New Functions: Microbiome and Inflammation

28 Apr 2018

Abstract excerpt

The biological functions of 1α,25-dihydroxyvitamin D3 are regulated by nuclear receptor vitamin D receptor (VDR). The expression level of VDR is high in intestine. VDR is an essential regulator of intestinal cell proliferation, barrier function, and immunity. Vitamin D/VDR plays a protective role in inflammatory bowel diseases (IBDs), both ulcerative colitis and Crohn's disease. Emerging evidence demonstrates low...

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PMID: 29718408
DOI: 10.1093/ibd/izy092

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