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Article

Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response.

The Journal of clinical investigation - 1 Sept 2021

Ranjan Kishu, Hedl Matija, Sinha Saloni, Zhang Xuchen, Abraham Clara

Abstract excerpt

Properly balancing microbial responses by the innate immune system through pattern recognition receptors (PRRs) is critical for intestinal immune homeostasis. Ring finger protein 186 (RNF186) genetic variants are associated with inflammatory bowel disease (IBD). However, functions for the E3 ubiquitin ligase RNF186 are incompletely defined. We found that upon stimulation of the PRR nucleotide-binding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 34623328
DOI: 10.1172/JCI145472
PMCID: PMC8409591

Genes

RNF186
ATF6
NOD2

Variants

rs6426833

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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