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Article

NAIL: an evolutionarily conserved lncRNA essential for licensing coordinated activation of p38 and NFκB in colitis

25 Nov 2020

Abstract excerpt

Objective NFκB is the key modulator in inflammatory disorders. However, the key regulators that activate, fine-tune or shut off NFκB activity in inflammatory conditions are poorly understood. In this study, we aim to investigate the roles that NFκB-specific long non-coding RNAs (lncRNAs) play in regulating inflammatory networks. Design Using the first genetic-screen to identify NFκB-specific lncRNAs, we performed...

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PMID: 33239342
DOI: 10.1136/gutjnl-2020-322980

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