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Article

TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease.

Gastroenterology - 1 Sept 2011

Nimmo Elaine R, Stevens Craig, Phillips Anne M, Smith Amanda, Drummond Hazel E, Noble Colin L, Quail Michael, Davies Gail, Aldhous Marian C, Wilson David C, Satsangi Jack

Abstract excerpt

BACKGROUND & AIMS: The mechanisms by which specific mutations in NOD2/CARD15 increase the risk for Crohn's disease (CD) are unclear. We identified proteins that interact with NOD2 and investigated them by expression, genetic, and functional analyses. METHODS: By using a yeast 2-hybrid screen of an intestinal epithelial library, we identified proteins that interact with NOD2 and confirmed the interactions in...

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Source

Identifiers

PMID: 21699783
DOI: 10.1053/j.gastro.2011.05.043

Genes

NOD2
TLE1
GALNT2
FIS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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