Article
ISG15 expression correlates with HIV-1 viral load and with factors regulating T cell response.
Immunobiology - 1 Feb 2016
Scagnolari Carolina, Monteleone Katia, Selvaggi Carla, Pierangeli Alessandra, D'Ettorre Gabriella, Mezzaroma Ivano, Turriziani Ombretta, Gentile Massimo, Vullo Vincenzo, Antonelli Guido
Abstract excerpt
Given the multifactorial nature of action of type I interferon (IFN) in HIV-1 infection and the need to firmly establish the action of key components of IFN pathways, we compared the IFN stimulated gene (ISG)15 expression with that of other well-characterized ISGs, evaluating its relationship with immunosuppressive factors regulating T-cell response in HIV-1 patients. PBMC from 225 subjects were included: healthy...
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