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Article

The interferon stimulated gene 15 functions as a proviral factor for the hepatitis C virus and as a regulator of the IFN response.

Gut - 1 Aug 2010

Broering Ruth, Zhang Xiaozhen, Kottilil Shyam, Trippler Martin, Jiang Min, Lu Mengji, Gerken Guido, Schlaak Joerg F

Abstract excerpt

BACKGROUND: Non-response to combination therapy by patients with hepatitis C virus (HCV) has previously been associated with a strong hepatic upregulation of interferon stimulated genes (ISGs) including ISG15. Therefore, the aim of this study was to further elucidate the functional role of this molecule. METHODS: ISG15 expression was suppressed by siRNAs or enhanced by over-expression in genomic and subgenomic...

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Source

Identifiers

PMID: 20639253
DOI: 10.1136/gut.2009.195545

Genes

ISG15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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