Article

ISG15 induces IL-10 production in human monocytes and is a biomarker of disease severity during active tuberculosis

2017-07-21

Abstract excerpt

Interferon stimulated gene 15 (ISG15) deficiency in humans leads to severe interferonopathies and mycobacterial disease, the latter being previously attributed to its extracellular cytokine-like activity. Here, we demonstrate a novel role for secreted ISG15 as an IL-10 inducer, unique to primary human monocytes. Employing ex vivo systems analysis of human transcriptome datasets, we observed a significant correlat...

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Literature Corpus work: 186c7f99-0eeb-55b3-ba9e-ac2c05579b0c
DOI: 10.1101/166553

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